Chagas disease or American trypanosomiasis is an important health problem in Latin America. Due to the mobility of Latin American population around the world, countries without vector presence started to report disease cases. We developed a deterministic compartmental model in order to gain insights into the disease dynamics in a scenario without vector presence, considering congenital transmission and transmission by blood transfusion. The model was used to evaluate the epidemiological effect of control measures. It was applied to demographic data from (...) Spain and sensitivity analysis was performed on model parameters associated with control strategies. (shrink)

El debate en torno a la antropología aborda aquí una cuestión de categorías fundamentales en torno a la estructura básica del ser humano: hombre y mujer, niño y anciano. La terminología articulada por la categoría «espíritu - pneuma» abre las posibilidades de una nueva comprensión ante los retos planteados por las ciencias experimentales, la ética, la moral, incluso la religión. El esquema diádico «cuerpo y alma» se muestra agotado ante los callejones sin salida con los que se ha encontrado al (...) llegar hasta nuestros días. Por este motivo, el artículo defiende poder recuperar la antropología brotando de los datos de la revelación judeocristiana, tomados como auténticos y válidos para vehicular la verdad de la realidad humana. En efecto, resulta necesario recuperar la originalidad de la estructura triádica de espíritu, alma y cuerpo, presentada por el apóstol Pablo, de forma totalmente inesperada en su primera carta a los Tesalonicenses (1Te 5,23). (shrink)

Recent trends towards an e-Science offer us the opportunity to think about the specific epistemological changes created by computational empowerment in scientific practices. In fact, we can say that a computational epistemology exists that requires our attention. By ‘computational epistemology’ I mean the computational processes implied or required to achieve human knowledge. In that category we can include AI, supercomputers, expert systems, distributed computation, imaging technologies, virtual instruments, middleware, robotics, grids or databases. Although several authors talk about the extended mind (...) and computational extensions of the human body, most of these proposals don’t analyze the deep epistemological implications of computer empowerment in scientific practices. At the same time, we must identify the principal concept for e-Science: Information . Why should we think about a new epistemology for e-Science? Because several processes exist around scientific information that require a good epistemological model to be understood. (shrink)

This paper provides estimates of the economic welfare effects of tobacco taxation in India, S.Africa, S.Korea, Japan and the European Union. It argues that past studies of the cost-benefits of smoking are flawed as they fail to net out Paretoirrelevant pecuniary externalities. It estimates tobacco demand for both the myopic and rational addiction models and finds the latter invariably perform better. It finds that the net welfare losses associated with current tax levels an increase over current taxation of 10% and (...) an increase of 10% a year for!0 years in all these countries, but particularly in the poorest, are large.Cet article fournit des estimations des effets des taxes sur le tabac sur le bien-être : l’Inde, l’Afrique du Sud, la Corée du Sud, le Japon et l’Union Européenne. L’article soutient que les analyses antérieures des coûts et des bénéfices de la cigarette sont erronées car elles ne tiennent pas compte des externalités pécuniaires non pertinentes dans un monde parétien. Il donne des estimations de la demande non tant pour les modèles myopes que pour ceux supposant une addiction rationnelle et constate que ces derniers donnent de meilleurs résultats. Il en ressort aussi que les pertes nettes de bien-être associées aux niveaux actuels de taxes, à une augmentation de 10% des taxes actuelles et à une augmentation annuelle de 10% des taxes sur 10 ans dans toutes les zones étudiées, mais particulièrement dans les plus pauvres d’entre elles, sont conséquentes. (shrink)

Currently, the concept of the cell as a society or an ecosystem of molecular elements is gaining increasing acceptance. The basic idea arose in the 19th century, from the surmise that there is not just a single unit underlying an individual’s appearance, but a plurality of entities with both collaborative and conflicting relationships. The following hypothesis is based around this model. The incompatible activities taking place between different original elements, which were subsumed into the first cell and could not be (...) eliminated, had to be controlled very closely. Similarly, a strong level of control had to be developed over many cellular elements after the cell changed its genome to DNA. We assume that at least some of those original RNA agents and other biomolecules which carry incompatibilities and risks, are retained within current cells, although they are now under strict control. A virus functions as a signal informing these repressed cellular RNAs and other elements of ancient origin how to restore suppressed degrees of molecular freedom, favoring pre-existing molecular affinities and activities, re-establishing ancient molecular webs of interactions, and giving fragments of ancient coded information the opportunity to be re-expressed. Collectively, these newly activated mechanisms lead to different possibilities for pathological cell states. All these processes are opposed by cell-control mechanisms. Thus, in this new scenario, the battle is considered intracellular rather than between the virus and the cell. And so the virus is treated as the signal that precipitates the cell’s change from a latent to an active pathological state. (shrink)

Cognitive symptoms after COVID-19 have been increasingly recognized several months after the acute infection and have been designated as “brain fog.” We report a patient with cognitive symptoms that started immediately after COVID-19, in which cerebrospinal fluid biomarkers were highly suggestive of Alzheimer’s disease. Our case highlights the need to examine patients with cognitive symptoms following COVID-19 comprehensively. A detailed assessment combining clinical, cognitive, and biomarker studies may help disentangle the underlying mechanisms associated with cognitive dysfunction in each case. The (...) investigation of neurodegenerative processes in an early stage, especially in older patients, is probably warranted. (shrink)

Recent trends towards an e-Science offer us the opportunity to think about the specific epistemological changes created by computational empowerment in scientific practices. In fact, we can say that a computational epistemology exists that requires our attention. By ‘computational epistemology’ I mean the computational processes implied or required to achieve human knowledge. In that category we can include AI, supercomputers, expert systems, distributed computation, imaging technologies, virtual instruments, middleware, robotics, grids or databases. Although several authors talk about the extended mind (...) and computational extensions of the human body, most of these proposals don’t analyze the deep epistemological implications of computer empowerment in scientific practices. At the same time, we must identify the principal concept for e-Science: Information. Why should we think about a new epistemology for e-Science? Because several processes exist around scientific information that require a good epistemological model to be understood. (shrink)

Desde la actual teoría general de la acción se han levantado objeciones contra lavalidez como saber transcendental de la Crítica de la razónpráctica. Se la acusa de haber deducido la libertad del «Faktum» moral en vez de deducir la moralidad de una libertad moralmente neutray íranscendentalmente ya asentada en el desarrollo crítico teórico. Un estudio atento de la obra revela, sin embargo, que en ella no se abandona la «reflexión» crítica y es justamente por ello que la moralidad puede entenderse (...) como la doctrina transcendental de la libertad. (shrink)

Responsible Research and Innovation (RRI) has only lately included environmental sustainability as a key area for the social desirability of research and innovation. That is one of the reasons why just a few RRI projects and proposals include environmental sustainability, and Climate Change (CC) in particular. CC is one of the grand challenges of our time and, thus, this paper contributes to the operationalization of CC prevention in RRI. To this end, the tools employed against CC were identified. Tools originated (...) in corporate social responsibility and sustainable innovation which help to operationalize strategies against CC in RRI practice. Complementarily, the latest proposals by RRI projects and actors related to CC were reviewed. The findings of the document analysis and the web review were arranged in a framework intended for research and innovation that has an indirect but relevant negative impact due to CC. Thus, four main strategies for CC prevention in RRI were determined: a voluntary integration of the aims, a life cycle perspective, open access databases and key performance indicators, and stakeholder management. The article is finished acknowledging diverse barriers hindering the operationalization of CC prevention in RRI, and we introduce future avenues for research in this area. (shrink)

My purpose in this essay is to clarify and evaluate Arthur Schopenhauer's grounds for the view that happiness is impossible. I shall distinguish two of his arguments for that view and argue that both of them are unsound. Both arguments involve premises grounded on a problematic view, namely, that desires have no objects. What makes this view problematic is that, in each of the two arguments, it conflicts with Schopenhauer's grounds for other premises in the argument. I shall then propose (...) a way of fixing both arguments. The solution involves substituting the view that desires have no objects with the view that we have a desire to have desires. The latter view, I shall argue, can do the grounding work that the former does in Schopenhauer's arguments but, unlike it, the view that we desire to desire is consistent with Schopenhauer's grounds for the rest of premises in those arguments. (shrink)

(Axiological Systems in the XXI century: A Collage. The downfall of axiological systems based on beliefs and the co-existence of varied beliefs in the spiritual market) - DOI – 10.5752/P.2175-5841.2012v10n28p1295 Resumen Pretendemos mostrar como los sistemas axiológicos de creencias provenientes de las religiones no están vigentes en la actualidad. Para ello mostramos algunos datos del Banco Mundial que muestran como los sistemas heterónomos de creencias no funcionan como orientadores de la vida personal y social del individuo. También facilitamos información sobre (...) la disminución de los que se autoadscriben como pertenecientes a un sistema de creencias y además demostramos mediante las estadísticas que no existe relación entre autoadscribirse como miembro de un sistema de creencias y mantener unas determinadas creencias. Clarificamos la noción de creencia comúnmente utilizada como supuesto acrítico y otros usos del lenguaje corriente y del lenguaje científico. Utilizamos estadísticas de Catalunya, España, y de algunos países de Europa y América. Concluimos que si los sistemas axiológicos de los individuos no vienen determinados por las religiones, entonces ¿qué sistemas axiológicos tenemos que sean capaces de cohesionar y motivar los individuos hacia fines valiosos comunes? Palabras clave : Sistemas Axiológicos. Creencias. Religión. Cualidad humana. Estadísticas. España católicaWe aim at showing why axiological systems coming from religion are not operative currently. To do this we show World Bank data where it is manifested that heteronomous systems of beliefs are not in force to orient the personal and social life of the individuals. We also communicate the declining numbers of those that register themselves as believers and we also reveal that there is no relationship between registering oneself as a believer in an axiological system and effectively holding and “believing” the beliefs of that axiological system. We clarify the common use of the term belief as a non-critical assumption, and other uses of the term in natural language and scientific language. We use statistical data for Catalonia, Spain and some countries of Europe and America. We conclude by asking if individuals’ axiological systems are not determined by religions, then What axiological systems do we have able to cohere and motivate individuals towards valuable common futures? Keywords: Axiological systems. Beliefs, Religion. Human Quality. Statistics. Spain Catholic. (shrink)

In this paper, I propose an account of self-knowledge for desires. According to this account, we form beliefs about our own desires on the basis of our grounds for those desires. First, I distinguish several types of desires and their corresponding grounds. Next, I make the case that we usually believe that we have a certain desire on the basis of our grounds for it. Then, I argue that a belief formed thus is epistemically privileged. Finally, I compare this account (...) to two other similar accounts of self-knowledge. (shrink)

The cross-cultural literature is reviewed and integrated together with attitude theories, thereby outlining a model through which certain values influence the intervening variables that ultimately lead managers to tolerate employee bribery. The case of Latin America is employed to illustrate how regionally dominant cultural values may shape managers' attitudes, subjective norms, and perceived behavioral control, which in turn affect tolerance of employee bribery. A series of research propositions and practical recommendations are derived from the model.

Editor's suggested further reading in BioEssays: Evolution in response to climate change: In pursuit of the missing evidence AbstractHow will fish that evolved at constant sub‐zero temperatures cope with global warming? Notothenioids as a case study Abstract.